360-degree full range of cooling and heating, freezing at minus 10℃ to positive 45℃ heating, 4 groups cycle modes for operation, parameters can be set flexibly; 8 pcs different sizes cryo handles are suitable for different size areas and body shape. Studies have shown that subcutaneous lipid rich cells can be selectively affected by cooling subcutaneous tissue to temperatures below 10 degrees celsius. Lipid rich cells can be affected by rupture, contraction, damage, destruction, removal, killing, or other changes. Without theoretical limitations, it is believed that the high selectivity of lipid rich cells is that they do not induce crystallization in non lipid rich cells, and that highly saturated fatty acids are locally crystallized. The crystals break into double membranes rich in lipid cells, which selectively cause necrosis of these cells. Therefore, it is possible to avoid the damage of non lipid rich cells, such as dermal cells, at the temperature induced by crystallization in lipid rich cells. Through the local cold exposure induced by stimulation of the sympathetic nervous system, increased lipolysis.